Antonio Lima-De-Faria, "Praise of Chromosome "Folly": Confessions of an Untamed Molecular Structure"
2008 | ISBN-10: 9812810943 | 428 pages | PDF | 6 MB
When examined carefully at the molecular level, the chromosome turns out to have created its own private world full of tricks, back door exits and novel solutions. This folly makes it an untamed innovator. Geneticists have been bewildered for decades. What kind of creature was actually the chromosome? Was it plastic, changing by innumerous rearrangements and mutations all the time; or was it a rigid structure which has preserved its basic organisation and functions since the dawn of the cell? It is this conflicting state that seems to be at the base of its folly . Perplexed by this behavior, cell biologists have called it a junkyard and even the ultimate parasite. Moreover, the chromosome has been regarded as a passive cell organelle prone to random mutations and subjected to the mercy of selection.
The latest molecular information discloses a radically different picture in which the chromosome appears as an independent molecular structure that follows its own path. It does not obey gravity, randomness, selection or magnetism.