» » Bioisosteres in Medicinal Chemistry

Information of news
  • Author: gravita
  • Date: 11-11-2013, 10:47
11-11-2013, 10:47

Bioisosteres in Medicinal Chemistry

Category: E-Books

Bioisosteres in Medicinal Chemistry
Bioisosteres in Medicinal Chemistry
Published: 2012-10-15 | ISBN: 3527330151 | PDF | 256 pages | 3 MB

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section

Link Download

Buy Premium Account To Support Me & Get Maximum Speed & Save Time!!


Site BBcode/HTML Code:

Tags to an Article: Bioisosteres, Medicinal, Chemistry

Dear visitor, you went to the site as unregistered user.
We recommend you Sign up or Login to website under your name.
Would you like to leave your comment? Please Login to your account to leave comments. Don't have an account? You can create a free account now.