» » GPCR Signalling Complex - Synthesis, Assembly, Trafficking and Specificity (Subcellular Biochemistry)



Information of news
  • Author: sheva370
  • Date: 27-10-2013, 22:24
27-10-2013, 22:24

GPCR Signalling Complex - Synthesis, Assembly, Trafficking and Specificity (Subcellular Biochemistry)

Category: E-Books

GPCR Signalling Complex - Synthesis, Assembly, Trafficking and Specificity (Subcellular Biochemistry)
GPCR Signalling Complexes - Synthesis, Assembly, Trafficking and Specificity (Subcellular Biochemistry)
English | 2012 | ISBN: 9400747640 | PDF | 298 pages | 8 Mb

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins.
Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.


Uploaded:
http://uploaded.net/file/a2kjqf2c/e6aj3.GPCR.Signalling.Complex..Synthesis.Assembly.Trafficking.and.Specificity.Subcellular.Biochemistry.pdf

RapidGator:
http://rapidgator.net/file/d7c876de015e76a9ee467ae47eebe263/e6aj3.GPCR.Signalling.Complex..Synthesis.Assembly.Trafficking.and.Specificity.Subcellular.Biochemistry.pdf.html

uploaded


Rapidgator.net
Site BBcode/HTML Code:

Tags to an Article: GPCR, Signalling, Complex, Synthesis, Assembly

Dear visitor, you went to the site as unregistered user.
We recommend you Sign up or Login to website under your name.
Information
Would you like to leave your comment? Please Login to your account to leave comments. Don't have an account? You can create a free account now.